產(chǎn)品信息 TGF-β家族成員廣泛存在于從果蠅到人多種生物的 各種組織中,對正常細胞、癌變細胞都有著顯著作用。TGF-β除了影響細胞的增殖、分化,還在胚胎發(fā)育、胞外基質(zhì)形成、 骨的形成和重建等方面起著重要作用。 ALK-5 A selective inhibitor of ALK5 (TGF-beta type I receptor). It has also been shown that this compound can replace Sox2 when reprogramming cells to iPS cells. 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE Ref: Gellibert, F., et al. (2004) Identification of 1, 5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47: 4494-4506. Ichida, J.K., et al. (2009) A small-molecule inhibitor of Tgf-beta signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 5: 491-503 Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. Biological Activity:Not determined. 重慶市華雅干細胞技術(shù)有限公司 |