產(chǎn)品信息 Hedgehog(Hh) 信號通路調節(jié)胚胎發(fā)育和成體許多組織器官干細胞的自我更新與增殖。然而,那些在正常發(fā)育過程中受到Hh信號通路調節(jié)的組織器官,在該信號通路異常時常常發(fā) 生腫瘤。這些腫瘤包括肝癌、神經(jīng)膠質瘤、基底細胞癌、橫紋肌肉瘤、胰腺癌、小細胞肺癌、胃癌、結腸癌、前列腺癌、黑色素瘤和多發(fā)性骨髓瘤等。 Purmorphamine: an agonist of SMO (smoothened). This small molecule compound activates the hedgehog pathway by directly binding to SMO. It has been shown to induce osteogenesis of mesenchymal stem cells. Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. Biological Activity: In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives EC50 of 1.0 uM. 重慶市華雅干細胞技術有限公司 |